PhD position on C–H activation

Design and synthesis of original chiral ligands for 3d-metal catalyzed asymmetric C-H activation


C-H activation is one of the most rapidly expanding fields of organic chemistry and homogeneous catalysis. However, the use of noble, poorly available, and expensive metal catalysts, such as Pd, Rh, Ru, and Ir considerably limits the sustainability of this field.[1] Accordingly, growing attention has been focused on developing alternative catalytic systems, based on the use of 3d-metals, such as Co, Ni, Mn, and Fe. In parallel, the synthesis of chiral molecules via C-H activation is still relatively limited; in particular, stereoselective catalytic systems based on using 3d-metals are clearly underdeveloped.[2] Therefore, the design of original, polyfunctional chiral Co-, Mn-, and Ni complexes able to promote asymmetric C-H activation appears as an attractive solution to overcome this limitation. The aim of this Ph.D. project is to design, synthesize, and evaluate the catalytic activity of conceptually new, “polyfunctionalized” chiral ligands, based on the axially chiral tetraphenyl scaffold.[3] These new ligands will be subsequently used in Co- and Ni-catalyzed C(sp2)-H and C(sp3)-H activation targeting the construction of original small chiral molecules, appealing building blocks for pharmaceutical and agrichemical industries.


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[1] P. Gandeepan, T. Müller, D. Zell, G. Cera, S. Warratz, L. Ackermann, Chem. Rev. 2019, 119, 2192–2452. [2] a) J. Loup, U. Dhawa, F. Pesciaioli, J. Wencel-Delord, L. Ackermann, Angew. Chem. Int. Ed. 2019, 58, 12803– 12818 ; b) Ł. Woźniak, N. Cramer, Trends in Chemistry 2019, 1, 471–484. [3] Q. Dherbassy, J.-P. Djukic, J. Wencel-Delord, F. Colobert, Angew. Chem. Int. Ed. 2018, 57, 4668–4672.


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202206 - PhD position - design and synthesis of original chiral ligands for 3d-metal catal
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