Post-doc position on hypervalent chlorines synthesis

Synthesis of hypervalent chlorines and their applications in organic synthesis

The last decades were clearly marked by the great development of the field of hypervalent iodines and thus these compounds are now extremely valuable reagents with a broad panel of applications in synthetic chemistry.[1] In clear contrast, other hypervalent compounds remain clearly an underdeveloped research field with rather limited applications. Indeed, while the synthesis of hypervalent iodines is very well established and robust, protocols affording other hypervalent compounds, such as bromanes and chloranes, are cruelly missing. Recently we have developed an operationally simple and efficient protocol to synthesize a variety of cyclic diarylbromanes and their unique reactivity, complementary to the reactivity of the corresponding iodanes, could be disclosed in metal-free reactions.[2] The aim of this Post-doc position is to go one step further and focus on the chemistry oh hypervalent chlorines. The researcher will design new, sustainable synthetic routes to access other original hypervalent chlorines. The newly accessed compounds will be fully characterized, and their physicochemical properties will be studied. Subsequently, the reactivity of the hypervalent chlorines will be compared with the corresponding hypervalent bromines and iodines. Finally, such original, highly reactive compounds will be used as new reagents for metal-free reactions, thus targeting sustainable synthesis.


[1] A. Yoshimura, V. V. Zhdankin, Chem. Rev. 2016, 116, 3328–3435. [2] a) M. Lanzi, Q. Dherbassy, J. Wencel-Delord, Angew. Chem. Int. Ed. 2021, 60, 14852–14857. b) M. Lanzi, R. A. Ali Abdine, M. De Abreu, J. Wencel-Delord, Org. Lett. 2021, 23, 9047–9052.


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202206 - Post-doc - Synthesis of hypervalent chlorines and their applications in organic s
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